Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Sox2  SRY (sex determining region Y)-box 2   (Synonyms: lcc, Sox-2, ysb)
Results	Reference
1	J:216617 Benito-Gonzalez A, Doetzlhofer A, Hey1 and Hey2 control the spatial and temporal pattern of mammalian auditory hair cell differentiation downstream of Hedgehog signaling. J Neurosci. 2014 Sep 17;34(38):12865-76
1	J:222780 Defourny J, Mateo Sanchez S, Schoonaert L, Robberecht W, Davy A, Nguyen L, Malgrange B, Cochlear supporting cell transdifferentiation and integration into hair cell layers by inhibition of ephrin-B2 signalling. Nat Commun. 2015;6:7017
1	J:253766 Dvorakova M, Jahan I, Macova I, Chumak T, Bohuslavova R, Syka J, Fritzsch B, Pavlinkova G, Incomplete and delayed Sox2 deletion defines residual ear neurosensory development and maintenance. Sci Rep. 2016 Dec 5;6:38253
1*	J:276652 Fang Q, Zhang Y, Da P, Shao B, Pan H, He Z, Cheng C, Li D, Guo J, Wu X, Guan M, Liao M, Zhang Y, Sha S, Zhou Z, Wang J, Wang T, Su K, Chai R, Chen F, Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function. Sci Rep. 2019 Mar 4;9(1):3357
1	J:231463 Haque K, Pandey AK, Zheng HW, Riazuddin S, Sha SH, Puligilla C, MEKK4 Signaling Regulates Sensory Cell Development and Function in the Mouse Inner Ear. J Neurosci. 2016 Jan 27;36(4):1347-61
1*	J:263979 Harley RJ, Murdy JP, Wang Z, Kelly MC, Ropp TF, Park SH, Maness PF, Manis PB, Coate TM, Neuronal cell adhesion molecule (NrCAM) is expressed by sensory cells in the cochlea and is necessary for proper cochlear innervation and sensory domain patterning during development. Dev Dyn. 2018 Mar 14;
1*	J:123544 Hume CR, Bratt DL, Oesterle EC, Expression of LHX3 and SOX2 during mouse inner ear development. Gene Expr Patterns. 2007 Aug;7(7):798-807
1	J:315409 Huyghe A, Van den Ackerveken P, Sacheli R, Prevot PP, Thelen N, Renauld J, Thiry M, Delacroix L, Nguyen L, Malgrange B, MicroRNA-124 Regulates Cell Specification in the Cochlea through Modulation of Sfrp4/5. Cell Rep. 2015 Oct 6;13(1):31-42
1*	J:202344 Lesko MH, Driskell RR, Kretzschmar K, Goldie SJ, Watt FM, Sox2 modulates the function of two distinct cell lineages in mouse skin. Dev Biol. 2013 Oct 1;382(1):15-26
1*	J:326361 Li S, Fan T, Li C, Wang Y, Li J, Liu Z, Fate-mapping analysis of cochlear cells expressing Atoh1 mRNA via a new Atoh1(3*HA-P2A-Cre) knockin mouse strain. Dev Dyn. 2022 Jul;251(7):1156-1174
1*	J:175285 Pan H, Schultz RM, Sox2 modulates reprogramming of gene expression in two-cell mouse embryos. Biol Reprod. 2011 Aug;85(2):409-16
1	J:217588 Perdigoto CN, Bardot ES, Valdes VJ, Santoriello FJ, Ezhkova E, Embryonic maturation of epidermal Merkel cells is controlled by a redundant transcription factor network. Development. 2014 Dec;141(24):4690-6
1*	J:311142 Sun H, Wang T, Atkinson PJ, Billings SE, Dong W, Cheng AG, Gpr125 Marks Distinct Cochlear Cell Types and Is Dispensable for Cochlear Development and Hearing. Front Cell Dev Biol. 2021;9:690955
1*	J:307862 Wilkerson BA, Zebroski HL, Finkbeiner CR, Chitsazan AD, Beach KE, Sen N, Zhang RC, Bermingham-McDonogh O, Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris. Elife. 2021 May 18;10:e60108
1	J:234179 Xiao Y, Thoresen DT, Miao L, Williams JS, Wang C, Atit RP, Wong SY, Brownell I, A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development. PLoS Genet. 2016 Jul;12(7):e1006150
1	J:286615 Yan X, Atorf J, Ramos D, Thiele F, Weber S, Dalke C, Sun M, Puk O, Michel D, Fuchs H, Klaften M, Przemeck GKH, Sabrautzki S, Favor J, Ruberte J, Kremers J, de Angelis MH, Graw J, Mutation in Bmpr1b Leads to Optic Disc Coloboma and Ventral Retinal Gliosis in Mice. Invest Ophthalmol Vis Sci. 2020 Feb 7;61(2):44
1	J:277430 Yang LM, Cheah KSE, Huh SH, Ornitz DM, Sox2 and FGF20 interact to regulate organ of Corti hair cell and supporting cell development in a spatially-graded manner. PLoS Genet. 2019 Jul;15(7):e1008254
1*	J:239360 Zhang Y, Chen Y, Ni W, Guo L, Lu X, Liu L, Li W, Sun S, Wang L, Li H, Dynamic expression of Lgr6 in the developing and mature mouse cochlea. Front Cell Neurosci. 2015;9:165